Drug interactions
Aluminum hydroxide / magnesium carbonate + Deferiprone
Severity: Moderate
Aluminum hydroxide / magnesium carbonate and Deferiprone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone chelates polyvalent cations such as aluminum and magnesium in the gut. Taken together with these antacids, deferiprone may be bound and its absorption reduced, which could weaken iron-chelating effect.
What this interaction means in plain words
Aluminum hydroxide / magnesium carbonate and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of deferiprone by polyvalent metal cations in the gastrointestinal tract reduces its absorption.
What to do
Separate deferiprone from aluminum- or magnesium-containing antacids by at least 4 hours. Monitor serum ferritin to confirm chelation efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
Frequently asked questions
Can I take Aluminum hydroxide / magnesium carbonate with Deferiprone?
MediHelp rates the interaction as moderate. Aluminum hydroxide / magnesium carbonate and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone chelates polyvalent cations such as aluminum and magnesium in the gut. Taken together with these antacids, deferiprone may be bound and its absorption reduced, which could weaken iron-chelating effect.
How serious is the interaction between Aluminum hydroxide / magnesium carbonate and Deferiprone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate deferiprone from aluminum- or magnesium-containing antacids by at least 4 hours. Monitor serum ferritin to confirm chelation efficacy.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Abemaciclib, Acalabrutinib, Ado-trastuzumab emtansine. The full list is on the Deferiprone page.
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