Drug interactions
Aluminum hydroxide / magnesium trisilicate + Pazopanib
Severity: Moderate
Aluminum hydroxide / magnesium trisilicate and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption depends on an acidic gastric environment, and antacids raise gastric pH. This may reduce pazopanib exposure and efficacy.
What this interaction means in plain words
Aluminum hydroxide / magnesium trisilicate and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH decreases pazopanib solubility and absorption.
What to do
Separate pazopanib and the antacid by at least 1 hour before or 2 hours after. Prefer short-acting antacids over PPIs or H2 antagonists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
Frequently asked questions
Can I take Aluminum hydroxide / magnesium trisilicate with Pazopanib?
MediHelp rates the interaction as moderate. Aluminum hydroxide / magnesium trisilicate and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib absorption depends on an acidic gastric environment, and antacids raise gastric pH. This may reduce pazopanib exposure and efficacy.
How serious is the interaction between Aluminum hydroxide / magnesium trisilicate and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate pazopanib and the antacid by at least 1 hour before or 2 hours after. Prefer short-acting antacids over PPIs or H2 antagonists.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib. The full list is on the Pazopanib page.
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