Drug interactions
Alvimopan + Amiodarone
Severity: Minor
Alvimopan and Amiodarone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase alvimopan concentrations through P-glycoprotein inhibition. Alvimopan is used short-term in hospital, so clinical impact is probably limited.
What this interaction means in plain words
Alvimopan and Amiodarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by amiodarone reduces efflux of alvimopan.
What to do
No dose change is required for the short course. Monitor for gastrointestinal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Alvimopan with Amiodarone?
MediHelp rates the interaction as minor. Alvimopan and Amiodarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may increase alvimopan concentrations through P-glycoprotein inhibition. Alvimopan is used short-term in hospital, so clinical impact is probably limited.
How serious is the interaction between Alvimopan and Amiodarone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required for the short course. Monitor for gastrointestinal adverse effects.
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