Drug interactions
Alvimopan + Clarithromycin
Severity: Minor
Alvimopan and Clarithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may inhibit P-glycoprotein and modestly increase alvimopan exposure. Alvimopan is used only short term in hospital, and the clinical effect is probably small.
What this interaction means in plain words
Alvimopan and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition reduces alvimopan efflux.
What to do
No dose adjustment is usually needed. Monitor for GI adverse effects during the short alvimopan course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Alvimopan with Clarithromycin?
MediHelp rates the interaction as minor. Alvimopan and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may inhibit P-glycoprotein and modestly increase alvimopan exposure. Alvimopan is used only short term in hospital, and the clinical effect is probably small.
How serious is the interaction between Alvimopan and Clarithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for GI adverse effects during the short alvimopan course.
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