Drug interactions
Alvimopan + Cyclosporin
Severity: Minor
Alvimopan and Cyclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase alvimopan levels, although clinical significance is uncertain. Alvimopan is only used short term in hospital.
What this interaction means in plain words
Alvimopan and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cyclosporine inhibits P-glycoprotein efflux of alvimopan.
What to do
No routine dose change is needed; monitor for gastrointestinal adverse effects during the short treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
Frequently asked questions
Can I take Alvimopan with Cyclosporin?
MediHelp rates the interaction as minor. Alvimopan and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may increase alvimopan levels, although clinical significance is uncertain. Alvimopan is only used short term in hospital.
How serious is the interaction between Alvimopan and Cyclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for gastrointestinal adverse effects during the short treatment course.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren. The full list is on the Cyclosporin page.
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