Drug interactions
Alvimopan + Erythromycin
Severity: Minor
Alvimopan and Erythromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may inhibit P-glycoprotein and slightly raise alvimopan levels. Alvimopan is given only short term in hospital and a clinically relevant effect has not been shown.
What this interaction means in plain words
Alvimopan and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by erythromycin reduces efflux of alvimopan.
What to do
No dose adjustment is needed. Be aware of increased gastrointestinal adverse effects such as nausea or abdominal pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Alvimopan with Erythromycin?
MediHelp rates the interaction as minor. Alvimopan and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin may inhibit P-glycoprotein and slightly raise alvimopan levels. Alvimopan is given only short term in hospital and a clinically relevant effect has not been shown.
How serious is the interaction between Alvimopan and Erythromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of increased gastrointestinal adverse effects such as nausea or abdominal pain.
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