Drug interactions
Alvimopan + Nifedipine
Severity: Minor
Alvimopan and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a P-glycoprotein substrate and weak modulator, and an effect on alvimopan exposure is theoretical. No clinically meaningful interaction is established.
What this interaction means in plain words
Alvimopan and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein interaction; the effect is not well characterized.
What to do
No specific action is required; monitor clinical response to alvimopan as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
- Amifostine + Nifedipine Major
Frequently asked questions
Can I take Alvimopan with Nifedipine?
MediHelp rates the interaction as minor. Alvimopan and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a P-glycoprotein substrate and weak modulator, and an effect on alvimopan exposure is theoretical. No clinically meaningful interaction is established.
How serious is the interaction between Alvimopan and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor clinical response to alvimopan as usual.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine. The full list is on the Nifedipine page.
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