Drug interactions
Alvimopan + Phenytoin
Severity: Minor
Alvimopan and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may induce intestinal P-glycoprotein and slightly lower alvimopan exposure. Alvimopan is given only briefly after bowel surgery and the clinical impact is likely small.
What this interaction means in plain words
Alvimopan and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible induction of P-glycoprotein efflux by phenytoin reducing alvimopan absorption; the effect is poorly characterized.
What to do
No dose change is needed. Monitor return of bowel function as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Alvimopan with Phenytoin?
MediHelp rates the interaction as minor. Alvimopan and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin may induce intestinal P-glycoprotein and slightly lower alvimopan exposure. Alvimopan is given only briefly after bowel surgery and the clinical impact is likely small.
How serious is the interaction between Alvimopan and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor return of bowel function as usual.
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