Drug interactions
Amifampridine + Citalopram
Severity: Moderate
Amifampridine and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine carries a dose-related risk of seizures. Citalopram can lower the seizure threshold, so using both may raise the chance of a seizure in susceptible patients.
What this interaction means in plain words
Amifampridine and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Citalopram belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic lowering of seizure threshold.
What to do
Use the lowest effective amifampridine dose and monitor for seizure activity, especially in patients with epilepsy or other risk factors. Consider an alternative antidepressant if seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Citalopram?
MediHelp rates the interaction as moderate. Amifampridine and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine carries a dose-related risk of seizures. Citalopram can lower the seizure threshold, so using both may raise the chance of a seizure in susceptible patients.
How serious is the interaction between Amifampridine and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective amifampridine dose and monitor for seizure activity, especially in patients with epilepsy or other risk factors. Consider an alternative antidepressant if seizures occur.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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