Drug interactions
Amifampridine + Donepezil
Severity: Moderate
Amifampridine and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine enhances acetylcholine release and donepezil inhibits its breakdown, so cholinergic stimulation may be increased. This may cause bradycardia, gastrointestinal upset, salivation and bronchospasm. Amifampridine also carries a seizure risk.
What this interaction means in plain words
Amifampridine and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Donepezil belongs to Central Nervous System.
Why it happens
Additive cholinergic effects from increased acetylcholine release and reduced acetylcholine breakdown.
What to do
Monitor heart rate, gastrointestinal and respiratory symptoms, and seizure activity when starting or adjusting either drug. Reduce the dose if cholinergic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifampridine and Donepezil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Donepezil?
MediHelp rates the interaction as moderate. Amifampridine and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine enhances acetylcholine release and donepezil inhibits its breakdown, so cholinergic stimulation may be increased. This may cause bradycardia, gastrointestinal upset, salivation and bronchospasm. Amifampridine also carries a seizure risk.
How serious is the interaction between Amifampridine and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, gastrointestinal and respiratory symptoms, and seizure activity when starting or adjusting either drug. Reduce the dose if cholinergic symptoms occur.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
