Drug interactions
Amifampridine + Fentanyl
Severity: Minor
Amifampridine and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine carries a dose-related seizure risk, and opioids may lower seizure threshold in some settings. The added risk is probably small but relevant in patients with a seizure history.
What this interaction means in plain words
Amifampridine and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amifampridine belongs to Central Nervous System; Fentanyl belongs to Musculoskeletal.
Why it happens
Possible additive lowering of seizure threshold; the mechanism is not well established.
What to do
Monitor for seizure activity, particularly in patients with epilepsy or on high amifampridine doses. Use the lowest effective doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Fentanyl?
MediHelp rates the interaction as minor. Amifampridine and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amifampridine carries a dose-related seizure risk, and opioids may lower seizure threshold in some settings. The added risk is probably small but relevant in patients with a seizure history.
How serious is the interaction between Amifampridine and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for seizure activity, particularly in patients with epilepsy or on high amifampridine doses. Use the lowest effective doses.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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