Drug interactions
Amifampridine + Isoniazid
Severity: Moderate
Amifampridine and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower the seizure threshold; amifampridine causes dose-related seizures and isoniazid can cause seizures, especially in overdose or with pyridoxine deficiency. Combined use may increase seizure risk. Isoniazid is also an NAT2 inhibitor of uncertain relevance to amifampridine, which is NAT2-metabolized.
What this interaction means in plain words
Amifampridine and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Additive lowering of seizure threshold, and possible reduced NAT2 acetylation of amifampridine.
What to do
Monitor for seizures and adverse effects, and keep amifampridine at the lowest effective dose. Consider pyridoxine supplementation with isoniazid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifampridine and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Isoniazid?
MediHelp rates the interaction as moderate. Amifampridine and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower the seizure threshold; amifampridine causes dose-related seizures and isoniazid can cause seizures, especially in overdose or with pyridoxine deficiency. Combined use may increase seizure risk. Isoniazid is also an NAT2 inhibitor of uncertain relevance to amifampridine, which is NAT2-metabolized.
How serious is the interaction between Amifampridine and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for seizures and adverse effects, and keep amifampridine at the lowest effective dose. Consider pyridoxine supplementation with isoniazid.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
