Drug interactions
Amifampridine + Ketamine
Severity: Moderate
Amifampridine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine can cause dose-related seizures. Ketamine has been associated with seizure activity in some settings, so coadministration may theoretically add to seizure risk.
What this interaction means in plain words
Amifampridine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Possible additive lowering of seizure threshold; the interaction is mainly theoretical.
What to do
Monitor for neurological signs and seizures when ketamine is used in patients taking amifampridine. Consider alternative anesthetic agents in patients with a seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Ketamine?
MediHelp rates the interaction as moderate. Amifampridine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine can cause dose-related seizures. Ketamine has been associated with seizure activity in some settings, so coadministration may theoretically add to seizure risk.
How serious is the interaction between Amifampridine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurological signs and seizures when ketamine is used in patients taking amifampridine. Consider alternative anesthetic agents in patients with a seizure history.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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