Drug interactions
Amifampridine + Pimozide
Severity: Moderate
Amifampridine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine can cause seizures in a dose-related way, and antipsychotics such as pimozide may lower the seizure threshold. Using them together may raise the risk of seizures.
What this interaction means in plain words
Amifampridine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive lowering of seizure threshold through pharmacodynamic effects.
What to do
Use the lowest effective amifampridine dose and monitor for seizure activity. Reconsider the combination in patients with a seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Pimozide?
MediHelp rates the interaction as moderate. Amifampridine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine can cause seizures in a dose-related way, and antipsychotics such as pimozide may lower the seizure threshold. Using them together may raise the risk of seizures.
How serious is the interaction between Amifampridine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective amifampridine dose and monitor for seizure activity. Reconsider the combination in patients with a seizure history.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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