Drug interactions
Amifampridine + Theophylline
Severity: Moderate
Amifampridine and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine carries a dose-related risk of seizures, and theophylline also lowers the seizure threshold, particularly at high serum concentrations. Using them together may raise the likelihood of seizures.
What this interaction means in plain words
Amifampridine and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Theophylline belongs to Respiratory.
Why it happens
Additive pharmacodynamic lowering of the seizure threshold; adenosine antagonism by theophylline plus potassium channel blockade by amifampridine.
What to do
Keep theophylline serum concentrations within the therapeutic range and use the lowest effective amifampridine dose. Counsel the patient on seizure precautions and reassess the need for both drugs if seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Theophylline?
MediHelp rates the interaction as moderate. Amifampridine and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine carries a dose-related risk of seizures, and theophylline also lowers the seizure threshold, particularly at high serum concentrations. Using them together may raise the likelihood of seizures.
How serious is the interaction between Amifampridine and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep theophylline serum concentrations within the therapeutic range and use the lowest effective amifampridine dose. Counsel the patient on seizure precautions and reassess the need for both drugs if seizures occur.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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