Drug interactions
Amifostine + Amiloride
Severity: Moderate
Amifostine and Amiloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and antihypertensive agents such as amiloride can worsen it. At chemotherapeutic doses of amifostine the risk is clinically important.
What this interaction means in plain words
Amifostine and Amiloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Amiloride belongs to Cardiovascular.
Why it happens
Additive hypotensive effects; amiloride reduces blood volume and blood pressure.
What to do
At chemotherapy doses, withhold amiloride for 24 hours before amifostine if possible, otherwise do not give amifostine. At lower radioprotective doses, monitor blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Amiloride?
MediHelp rates the interaction as moderate. Amifostine and Amiloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and antihypertensive agents such as amiloride can worsen it. At chemotherapeutic doses of amifostine the risk is clinically important.
How serious is the interaction between Amifostine and Amiloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: At chemotherapy doses, withhold amiloride for 24 hours before amifostine if possible, otherwise do not give amifostine. At lower radioprotective doses, monitor blood pressure closely.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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