Drug interactions
Amifostine + Atenolol-chlorthalidone
Severity: Moderate
Amifostine and Atenolol-chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and antihypertensive drugs such as atenolol and chlorthalidone can add to this effect. At chemotherapeutic doses the combination may cause significant hypotension.
What this interaction means in plain words
Amifostine and Atenolol-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Atenolol-chlorthalidone belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through beta blockade, diuresis and the vasodilatory/hypotensive effect of amifostine.
What to do
When amifostine is given at chemotherapeutic doses, withhold antihypertensives for 24 hours beforehand if possible, and do not give amifostine if they cannot be held. Ensure adequate hydration and monitor blood pressure during infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Atenolol-chlorthalidone?
MediHelp rates the interaction as moderate. Amifostine and Atenolol-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and antihypertensive drugs such as atenolol and chlorthalidone can add to this effect. At chemotherapeutic doses the combination may cause significant hypotension.
How serious is the interaction between Amifostine and Atenolol-chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When amifostine is given at chemotherapeutic doses, withhold antihypertensives for 24 hours beforehand if possible, and do not give amifostine if they cannot be held. Ensure adequate hydration and monitor blood pressure during infusion.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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