Drug interactions
Amifostine + Olanzapine
Severity: Moderate
Amifostine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and olanzapine's alpha-1 blockade may add to this effect. The result can be dizziness, syncope or falls during infusion.
What this interaction means in plain words
Amifostine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Olanzapine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects through alpha-adrenergic blockade and amifostine-related vasodilation.
What to do
Monitor blood pressure before and during amifostine infusion. Consider holding antihypertensive or other hypotension-causing drugs as directed by the amifostine labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Olanzapine?
MediHelp rates the interaction as moderate. Amifostine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and olanzapine's alpha-1 blockade may add to this effect. The result can be dizziness, syncope or falls during infusion.
How serious is the interaction between Amifostine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion. Consider holding antihypertensive or other hypotension-causing drugs as directed by the amifostine labeling.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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