Drug interactions
Amiloride + Aspirin / citric acid / sodium bicarbonate
Severity: Moderate
Amiloride and Aspirin / citric acid / sodium bicarbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin component, at analgesic doses, can impair renal function and increase potassium retention with amiloride. The sodium bicarbonate component may add a sodium load and alkalinize urine.
What this interaction means in plain words
Amiloride and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandins, reducing potassium excretion, in addition to amiloride's ENaC blockade.
What to do
Limit use to short courses and monitor potassium and renal function in at-risk patients. Avoid in CKD or in patients with heart failure sensitive to sodium load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Aspirin / citric acid / sodium bicarbonate?
MediHelp rates the interaction as moderate. Amiloride and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin component, at analgesic doses, can impair renal function and increase potassium retention with amiloride. The sodium bicarbonate component may add a sodium load and alkalinize urine.
How serious is the interaction between Amiloride and Aspirin / citric acid / sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses and monitor potassium and renal function in at-risk patients. Avoid in CKD or in patients with heart failure sensitive to sodium load.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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