Drug interactions
Amiloride + Aspirin
Severity: Moderate
Amiloride and Aspirin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses, aspirin may impair renal function and blunt diuretic effects, increasing potassium retention risk with amiloride. Low-dose aspirin carries much less risk.
What this interaction means in plain words
Amiloride and Aspirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandins reduces renal blood flow and potassium and sodium excretion, adding to amiloride's effect.
What to do
Monitor potassium and renal function when higher aspirin doses are used. Low-dose cardioprotective aspirin generally needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Aspirin?
MediHelp rates the interaction as moderate. Amiloride and Aspirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses, aspirin may impair renal function and blunt diuretic effects, increasing potassium retention risk with amiloride. Low-dose aspirin carries much less risk.
How serious is the interaction between Amiloride and Aspirin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and renal function when higher aspirin doses are used. Low-dose cardioprotective aspirin generally needs no change.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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