Drug interactions
Amiloride + Bretylium
Severity: Moderate
Amiloride and Bretylium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium commonly causes hypotension, and amiloride may contribute to a further fall in blood pressure. The combination may cause symptomatic hypotension.
What this interaction means in plain words
Amiloride and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from adrenergic neuron blockade and diuretic-related volume reduction.
What to do
Monitor blood pressure closely during bretylium therapy and adjust or withhold amiloride if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Bretylium?
MediHelp rates the interaction as moderate. Amiloride and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium commonly causes hypotension, and amiloride may contribute to a further fall in blood pressure. The combination may cause symptomatic hypotension.
How serious is the interaction between Amiloride and Bretylium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during bretylium therapy and adjust or withhold amiloride if hypotension develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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