Drug interactions
Amiloride + Carbenoxolone
Severity: Moderate
Amiloride and Carbenoxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that promotes potassium loss and sodium and fluid retention, whereas amiloride conserves potassium. The two effects partly offset one another, but carbenoxolone also tends to raise blood pressure and can blunt the diuretic and antihypertensive benefit of amiloride.
What this interaction means in plain words
Amiloride and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid-like sodium retention and potassium wasting that opposes amiloride's ENaC blockade.
What to do
Monitor serum potassium, blood pressure and fluid status when the two are combined. Adjust the doses based on potassium results and watch for edema or loss of blood pressure control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Carbenoxolone?
MediHelp rates the interaction as moderate. Amiloride and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that promotes potassium loss and sodium and fluid retention, whereas amiloride conserves potassium. The two effects partly offset one another, but carbenoxolone also tends to raise blood pressure and can blunt the diuretic and antihypertensive benefit of amiloride.
How serious is the interaction between Amiloride and Carbenoxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, blood pressure and fluid status when the two are combined. Adjust the doses based on potassium results and watch for edema or loss of blood pressure control.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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