Drug interactions
Amiloride + Celiprolol
Severity: Moderate
Amiloride and Celiprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can modestly raise serum potassium by impairing cellular potassium uptake, and amiloride is a potassium-sparing diuretic. Together they can add to the risk of hyperkalemia, particularly in patients with renal impairment or diabetes.
What this interaction means in plain words
Amiloride and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effect: amiloride reduces renal potassium excretion while beta-blockade reduces beta-2 mediated cellular potassium uptake.
What to do
Check serum potassium and renal function at the start of combined therapy and periodically afterwards. Use extra vigilance in patients with reduced renal function or diabetes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Celiprolol?
MediHelp rates the interaction as moderate. Amiloride and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can modestly raise serum potassium by impairing cellular potassium uptake, and amiloride is a potassium-sparing diuretic. Together they can add to the risk of hyperkalemia, particularly in patients with renal impairment or diabetes.
How serious is the interaction between Amiloride and Celiprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at the start of combined therapy and periodically afterwards. Use extra vigilance in patients with reduced renal function or diabetes.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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