Drug interactions
Amiloride + Choline magnesium trisalicylate
Severity: Moderate
Amiloride and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can reduce renal prostaglandin synthesis, which may blunt the diuretic and antihypertensive effects of amiloride and reduce renal function. Together with amiloride's potassium-sparing action, this raises the risk of hyperkalemia and acute kidney injury, especially in volume-depleted or older patients.
What this interaction means in plain words
Amiloride and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-mediated prostaglandin inhibition lowers renal blood flow and potassium excretion, adding to amiloride's ENaC-mediated potassium retention.
What to do
Monitor serum potassium, creatinine and blood pressure, and ensure adequate hydration. Use the lowest effective salicylate dose or consider an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Amiloride and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can reduce renal prostaglandin synthesis, which may blunt the diuretic and antihypertensive effects of amiloride and reduce renal function. Together with amiloride's potassium-sparing action, this raises the risk of hyperkalemia and acute kidney injury, especially in volume-depleted or older patients.
How serious is the interaction between Amiloride and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure, and ensure adequate hydration. Use the lowest effective salicylate dose or consider an alternative analgesic in high-risk patients.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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