Drug interactions
Amiloride + Cyclopenthiazide
Severity: Minor
Amiloride and Cyclopenthiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride and thiazide-type diuretics are frequently used together because amiloride counteracts potassium loss from the thiazide. Their effects on potassium are opposing, but electrolyte disturbances such as hyponatremia or hyperkalemia can still occur, mainly in renal impairment.
What this interaction means in plain words
Amiloride and Cyclopenthiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Amiloride blocks collecting-duct ENaC and conserves potassium, while cyclopenthiazide blocks the distal tubule sodium-chloride cotransporter and increases potassium excretion.
What to do
Monitor serum potassium, sodium and renal function periodically, especially after dose changes or in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Cyclopenthiazide?
MediHelp rates the interaction as minor. Amiloride and Cyclopenthiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiloride and thiazide-type diuretics are frequently used together because amiloride counteracts potassium loss from the thiazide. Their effects on potassium are opposing, but electrolyte disturbances such as hyponatremia or hyperkalemia can still occur, mainly in renal impairment.
How serious is the interaction between Amiloride and Cyclopenthiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and renal function periodically, especially after dose changes or in older patients.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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