Drug interactions
Amiloride + Cyclosporine
Severity: Major
Amiloride and Cyclosporine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents reduce renal potassium excretion, so combined use can cause severe hyperkalemia, particularly with renal impairment.
What this interaction means in plain words
Amiloride and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Amiloride blocks the epithelial sodium channel and cyclosporine impairs tubular potassium secretion, giving additive hyperkalemia.
What to do
Avoid if possible; otherwise monitor serum potassium and creatinine frequently and avoid potassium supplements.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Cyclosporine?
MediHelp rates the interaction as major. Amiloride and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents reduce renal potassium excretion, so combined use can cause severe hyperkalemia, particularly with renal impairment.
How serious is the interaction between Amiloride and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor serum potassium and creatinine frequently and avoid potassium supplements.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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