Drug interactions
Amiloride + Dichlorphenamide
Severity: Moderate
Amiloride and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can promote metabolic acidosis, and combined use may worsen acid-base disturbance. Acidosis can also shift potassium out of cells, compounding the hyperkalemia risk from amiloride.
What this interaction means in plain words
Amiloride and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Carbonic anhydrase inhibition causes bicarbonate loss, and amiloride reduces renal acid and potassium excretion, producing additive acidosis.
What to do
Monitor serum bicarbonate, potassium and renal function periodically, and reduce doses or stop one agent if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Amiloride with Dichlorphenamide?
MediHelp rates the interaction as moderate. Amiloride and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can promote metabolic acidosis, and combined use may worsen acid-base disturbance. Acidosis can also shift potassium out of cells, compounding the hyperkalemia risk from amiloride.
How serious is the interaction between Amiloride and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate, potassium and renal function periodically, and reduce doses or stop one agent if acidosis develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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