Drug interactions
Amiloride + Fenbufen
Severity: Moderate
Amiloride and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can reduce renal prostaglandin synthesis, leading to sodium retention, reduced diuretic effect and impaired renal function. Combined with amiloride, this increases the risk of hyperkalemia and acute kidney injury, especially in older or dehydrated patients.
What this interaction means in plain words
Amiloride and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandins suppresses renin-aldosterone signaling and renal perfusion, adding to amiloride's potassium retention.
What to do
Monitor serum potassium, creatinine and blood pressure, and keep the patient hydrated. Prefer the shortest NSAID course or an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Fenbufen?
MediHelp rates the interaction as moderate. Amiloride and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can reduce renal prostaglandin synthesis, leading to sodium retention, reduced diuretic effect and impaired renal function. Combined with amiloride, this increases the risk of hyperkalemia and acute kidney injury, especially in older or dehydrated patients.
How serious is the interaction between Amiloride and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure, and keep the patient hydrated. Prefer the shortest NSAID course or an alternative analgesic in high-risk patients.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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