Drug interactions
Amiloride + Fenoprofen
Severity: Major
Amiloride and Fenoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can cause potassium retention and reduce renal function, and amiloride is a potassium-sparing diuretic. Together they can produce clinically significant hyperkalemia, particularly in renal impairment, diabetes or older age. NSAIDs also blunt the diuretic effect.
What this interaction means in plain words
Amiloride and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAIDs suppress prostaglandin-mediated renin and aldosterone release and reduce renal blood flow, while amiloride blocks renal potassium excretion.
What to do
Check serum potassium and creatinine at baseline and shortly after starting, then periodically. Avoid the combination in patients with renal impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Fenoprofen?
MediHelp rates the interaction as major. Amiloride and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can cause potassium retention and reduce renal function, and amiloride is a potassium-sparing diuretic. Together they can produce clinically significant hyperkalemia, particularly in renal impairment, diabetes or older age. NSAIDs also blunt the diuretic effect.
How serious is the interaction between Amiloride and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine at baseline and shortly after starting, then periodically. Avoid the combination in patients with renal impairment.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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