Drug interactions
Amiloride + Fentanyl
Severity: Minor
Amiloride and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and cause urinary retention, which may blunt the effect of a diuretic. The effect is generally modest and variable.
What this interaction means in plain words
Amiloride and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Opioid-induced antidiuretic hormone release and urinary retention may counteract diuretic effect.
What to do
Monitor fluid balance, weight, blood pressure and urine output. Adjust the diuretic dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Fentanyl?
MediHelp rates the interaction as minor. Amiloride and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release and cause urinary retention, which may blunt the effect of a diuretic. The effect is generally modest and variable.
How serious is the interaction between Amiloride and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid balance, weight, blood pressure and urine output. Adjust the diuretic dose if response is reduced.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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