Drug interactions
Amiloride + Formoterol
Severity: Minor
Amiloride and Formoterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium through beta2-mediated cellular uptake, while amiloride conserves potassium and can cause hyperkalemia. The two effects tend to offset one another, so a clinically significant change is unlikely in most patients, though potassium may be unpredictable in renal impairment or acute illness.
What this interaction means in plain words
Amiloride and Formoterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Formoterol belongs to Respiratory.
Why it happens
Opposing effects on serum potassium: beta2-agonist intracellular shift versus reduced renal excretion from ENaC blockade.
What to do
No routine action is needed; monitor serum potassium in patients with renal impairment, diabetes, or severe asthma/COPD exacerbation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiloride and Formoterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Formoterol?
MediHelp rates the interaction as minor. Amiloride and Formoterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Formoterol can lower serum potassium through beta2-mediated cellular uptake, while amiloride conserves potassium and can cause hyperkalemia. The two effects tend to offset one another, so a clinically significant change is unlikely in most patients, though potassium may be unpredictable in renal impairment or acute illness.
How serious is the interaction between Amiloride and Formoterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor serum potassium in patients with renal impairment, diabetes, or severe asthma/COPD exacerbation.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
