Drug interactions
Amiloride + Heparin
Severity: Moderate
Amiloride and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin suppresses aldosterone synthesis and can cause hyperkalemia, which adds to the potassium-retaining effect of amiloride. The risk is greater with renal impairment, diabetes or prolonged heparin use.
What this interaction means in plain words
Amiloride and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone secretion while amiloride blocks renal potassium excretion, producing additive hyperkalemia.
What to do
Monitor serum potassium during heparin therapy lasting beyond a few days or in patients with renal impairment. Stop amiloride if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Amiloride with Heparin?
MediHelp rates the interaction as moderate. Amiloride and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin suppresses aldosterone synthesis and can cause hyperkalemia, which adds to the potassium-retaining effect of amiloride. The risk is greater with renal impairment, diabetes or prolonged heparin use.
How serious is the interaction between Amiloride and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during heparin therapy lasting beyond a few days or in patients with renal impairment. Stop amiloride if hyperkalemia develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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