Drug interactions
Amiloride + Indapamide
Severity: Moderate
Amiloride and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide wastes potassium while amiloride retains it, so the combination is often used deliberately to balance potassium. However, hyperkalemia can occur, especially in renal impairment, older patients or those on other potassium-raising drugs.
What this interaction means in plain words
Amiloride and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Opposing renal potassium effects: thiazide-like kaliuresis versus amiloride ENaC blockade reducing potassium excretion.
What to do
Check serum potassium and renal function at baseline, within the first weeks and periodically thereafter. Avoid potassium supplements unless hypokalemia is documented.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Indapamide?
MediHelp rates the interaction as moderate. Amiloride and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide wastes potassium while amiloride retains it, so the combination is often used deliberately to balance potassium. However, hyperkalemia can occur, especially in renal impairment, older patients or those on other potassium-raising drugs.
How serious is the interaction between Amiloride and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline, within the first weeks and periodically thereafter. Avoid potassium supplements unless hypokalemia is documented.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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