Drug interactions
Amiloride + Ketorolac intranasal
Severity: Moderate
Amiloride and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically after intranasal use and, as an NSAID, can reduce renal perfusion and prostaglandin-dependent potassium excretion. With amiloride this raises the risk of hyperkalemia and acute kidney injury, and may weaken the diuretic effect.
What this interaction means in plain words
Amiloride and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-mediated prostaglandin inhibition reduces renal blood flow and renin-aldosterone activity, adding to amiloride's potassium retention.
What to do
Limit ketorolac to the shortest course, keep the patient hydrated, and monitor serum potassium and creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Amiloride and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is absorbed systemically after intranasal use and, as an NSAID, can reduce renal perfusion and prostaglandin-dependent potassium excretion. With amiloride this raises the risk of hyperkalemia and acute kidney injury, and may weaken the diuretic effect.
How serious is the interaction between Amiloride and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course, keep the patient hydrated, and monitor serum potassium and creatinine.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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