Drug interactions
Amiloride + Meclofenamate
Severity: Moderate
Amiloride and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can reduce renal prostaglandin production, causing sodium retention, diminished diuretic effect and decreased renal function. With amiloride, the risk of hyperkalemia and acute kidney injury is increased.
What this interaction means in plain words
Amiloride and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID prostaglandin inhibition lowers renal perfusion and aldosterone-related potassium excretion, adding to amiloride's potassium retention.
What to do
Monitor serum potassium, creatinine and blood pressure, and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Meclofenamate?
MediHelp rates the interaction as moderate. Amiloride and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can reduce renal prostaglandin production, causing sodium retention, diminished diuretic effect and decreased renal function. With amiloride, the risk of hyperkalemia and acute kidney injury is increased.
How serious is the interaction between Amiloride and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure, and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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