Drug interactions
Amiloride + Nitroglycerin rectal
Severity: Minor
Amiloride and Nitroglycerin rectal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, so combined use may cause additive hypotension. Dizziness or fainting is more likely when treatment is started or doses are increased.
What this interaction means in plain words
Amiloride and Nitroglycerin rectal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering from nitrate vasodilation and diuretic-induced volume reduction.
What to do
Check blood pressure and orthostatic symptoms when starting or changing either drug. Reduce one dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Nitroglycerin rectal?
MediHelp rates the interaction as minor. Amiloride and Nitroglycerin rectal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can lower blood pressure, so combined use may cause additive hypotension. Dizziness or fainting is more likely when treatment is started or doses are increased.
How serious is the interaction between Amiloride and Nitroglycerin rectal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure and orthostatic symptoms when starting or changing either drug. Reduce one dose if symptomatic hypotension occurs.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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