Drug interactions
Amiloride + Olanzapine / samidorphan
Severity: Minor
Amiloride and Olanzapine / samidorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may add to the blood pressure lowering of antihypertensives, including diuretics such as amiloride. Patients may experience dizziness or falls, especially at the start of therapy or after dose increases.
What this interaction means in plain words
Amiloride and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effect from olanzapine's alpha-1 adrenergic blockade combined with amiloride's diuretic and antihypertensive action.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting olanzapine, and reduce the amiloride dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Olanzapine / samidorphan?
MediHelp rates the interaction as minor. Amiloride and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine can cause orthostatic hypotension and may add to the blood pressure lowering of antihypertensives, including diuretics such as amiloride. Patients may experience dizziness or falls, especially at the start of therapy or after dose increases.
How serious is the interaction between Amiloride and Olanzapine / samidorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting olanzapine, and reduce the amiloride dose if hypotension occurs.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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