Drug interactions
Amiloride + Propranolol
Severity: Moderate
Amiloride and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride retains potassium, and non-selective beta-blockers such as propranolol can impair cellular potassium uptake. Together they may raise serum potassium, especially in patients with renal impairment or diabetes.
What this interaction means in plain words
Amiloride and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Amiloride blocks renal sodium channels and reduces potassium excretion, while propranolol blocks beta-2-mediated cellular potassium uptake.
What to do
Check serum potassium and renal function when starting the combination and periodically afterwards. Reduce or stop amiloride if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Amiloride with Propranolol?
MediHelp rates the interaction as moderate. Amiloride and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiloride retains potassium, and non-selective beta-blockers such as propranolol can impair cellular potassium uptake. Together they may raise serum potassium, especially in patients with renal impairment or diabetes.
How serious is the interaction between Amiloride and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when starting the combination and periodically afterwards. Reduce or stop amiloride if potassium rises.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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