Drug interactions
Amiloride + Quinapril
Severity: Major
Amiloride and Quinapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce renal potassium excretion, so combined use can cause dangerous hyperkalemia. Risk is higher with renal impairment, diabetes, older age or potassium supplements.
What this interaction means in plain words
Amiloride and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
ACE inhibition lowers aldosterone while amiloride blocks the epithelial sodium channel, producing additive potassium retention.
What to do
Measure potassium and creatinine at baseline, within the first week and periodically thereafter. Avoid potassium supplements and salt substitutes and stop amiloride if potassium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Quinapril?
MediHelp rates the interaction as major. Amiloride and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs reduce renal potassium excretion, so combined use can cause dangerous hyperkalemia. Risk is higher with renal impairment, diabetes, older age or potassium supplements.
How serious is the interaction between Amiloride and Quinapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure potassium and creatinine at baseline, within the first week and periodically thereafter. Avoid potassium supplements and salt substitutes and stop amiloride if potassium rises.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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