Drug interactions
Amiloride + Tenofovir df
Severity: Moderate
Amiloride and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amiloride and tenofovir are eliminated by the kidney partly through tubular secretion, so they may compete for renal elimination. Higher exposure to either drug is possible, and tenofovir also carries a risk of renal tubular toxicity, which could worsen potassium handling with amiloride.
What this interaction means in plain words
Amiloride and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible competition for active renal tubular secretion, with additive renal risk from tenofovir nephrotoxicity.
What to do
Monitor renal function and serum potassium periodically during combined use. Check for tenofovir-related tubular toxicity and reassess the combination if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Tenofovir df?
MediHelp rates the interaction as moderate. Amiloride and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both amiloride and tenofovir are eliminated by the kidney partly through tubular secretion, so they may compete for renal elimination. Higher exposure to either drug is possible, and tenofovir also carries a risk of renal tubular toxicity, which could worsen potassium handling with amiloride.
How serious is the interaction between Amiloride and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum potassium periodically during combined use. Check for tenofovir-related tubular toxicity and reassess the combination if renal function declines.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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