Drug interactions
Amiloride + Tenofovir disoproxil
Severity: Minor
Amiloride and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tenofovir and amiloride are secreted by renal tubular cationic and organic transport pathways. Competition at this step may raise concentrations of either drug, and amiloride carries a risk of hyperkalemia if renal function falls.
What this interaction means in plain words
Amiloride and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion, reducing clearance of each drug.
What to do
Monitor serum potassium and creatinine periodically. Reassess the amiloride dose if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Amiloride and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both tenofovir and amiloride are secreted by renal tubular cationic and organic transport pathways. Competition at this step may raise concentrations of either drug, and amiloride carries a risk of hyperkalemia if renal function falls.
How serious is the interaction between Amiloride and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine periodically. Reassess the amiloride dose if renal function declines.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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