Drug interactions
Amiloride + Trimethoprim
Severity: Major
Amiloride and Trimethoprim: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim blocks the same distal tubular sodium channels as amiloride, so combining them can cause clinically significant hyperkalemia.
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
Drug class
- Amiloride
- Cardiovascular
- Trimethoprim
- Anti Bacterial
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