Drug interactions
Aminohippurate + Fenoprofen
Severity: Minor
Aminohippurate and Fenoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are organic anions secreted by renal tubular transporters, so fenoprofen can compete with aminohippurate and reduce its tubular secretion. This may lead to an underestimate of renal plasma flow when aminohippurate is used as a diagnostic.
What this interaction means in plain words
Aminohippurate and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated renal tubular secretion.
What to do
Consider withholding the NSAID before renal plasma flow testing, if clinically feasible. Otherwise interpret the result with this effect in mind.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Aminohippurate with Fenoprofen?
MediHelp rates the interaction as minor. Aminohippurate and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are organic anions secreted by renal tubular transporters, so fenoprofen can compete with aminohippurate and reduce its tubular secretion. This may lead to an underestimate of renal plasma flow when aminohippurate is used as a diagnostic.
How serious is the interaction between Aminohippurate and Fenoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding the NSAID before renal plasma flow testing, if clinically feasible. Otherwise interpret the result with this effect in mind.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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