Drug interactions
Aminohippurate + Methotrexate
Severity: Moderate
Aminohippurate and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminohippurate competes with methotrexate for renal tubular secretion, which can reduce methotrexate clearance. Higher methotrexate levels raise the risk of myelosuppression and mucosal and renal toxicity.
What this interaction means in plain words
Aminohippurate and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for organic anion transporters (OAT1/OAT3) in the renal proximal tubule reduces methotrexate secretion.
What to do
Monitor methotrexate levels where feasible, along with renal function and blood counts. Avoid aminohippurate testing around high-dose methotrexate if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Aminohippurate with Methotrexate?
MediHelp rates the interaction as moderate. Aminohippurate and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminohippurate competes with methotrexate for renal tubular secretion, which can reduce methotrexate clearance. Higher methotrexate levels raise the risk of myelosuppression and mucosal and renal toxicity.
How serious is the interaction between Aminohippurate and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor methotrexate levels where feasible, along with renal function and blood counts. Avoid aminohippurate testing around high-dose methotrexate if possible.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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