Drug interactions
Albuterol + Amitriptyline
Severity: Moderate
Albuterol and Amitriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may enhance the cardiovascular effects of albuterol, such as tachycardia, palpitations and blood pressure changes. This is mainly a concern with systemic or high-dose albuterol and in patients with heart disease. Occasional inhaled use is usually tolerated.
What this interaction means in plain words
Albuterol and Amitriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics inhibit norepinephrine reuptake and may potentiate vascular and cardiac responses to beta-agonists.
What to do
Monitor heart rate, rhythm and blood pressure, especially with frequent or high-dose albuterol. Use the lowest effective bronchodilator dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Albuterol with Amitriptyline?
MediHelp rates the interaction as moderate. Albuterol and Amitriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may enhance the cardiovascular effects of albuterol, such as tachycardia, palpitations and blood pressure changes. This is mainly a concern with systemic or high-dose albuterol and in patients with heart disease. Occasional inhaled use is usually tolerated.
How serious is the interaction between Albuterol and Amitriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, especially with frequent or high-dose albuterol. Use the lowest effective bronchodilator dose.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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