Drug reference
amitriptyline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Tricyclic Antidepressants)
Mechanism of action
Neurotransmitter (especially norepinephrine and serotonin) reuptake inhibitor; anticholinergic
Common side effects
- Alopecia
- Agitation
- Anorexia
- Anxiety
- Agranulocytosis
- Ataxia
- Arrhythmia
Known interactions (11)
- amitriptyline + isocarboxazid Contraindicated
- amitriptyline + phenelzine Contraindicated
- amitriptyline + pimozide Contraindicated
- amitriptyline + procarbazine Contraindicated
- amitriptyline + safinamide Contraindicated
- amitriptyline + selegiline Contraindicated
- amitriptyline + tranylcypromine Contraindicated
- amitriptyline + quinidine Major
- amitriptyline + sotalol Major
- amitriptyline + dronedarone Moderate
- amitriptyline + indapamide Moderate
Related conditions
Frequently asked questions
What drug class is amitriptyline?
amitriptyline belongs to: Central Nervous System.
How does amitriptyline work?
Neurotransmitter (especially norepinephrine and serotonin) reuptake inhibitor; anticholinergic
What are the common side effects of amitriptyline?
Alopecia, Agitation, Anorexia, Anxiety, Agranulocytosis, Ataxia, Arrhythmia
Which drugs interact with amitriptyline?
isocarboxazid, phenelzine, pimozide, procarbazine, safinamide, selegiline, tranylcypromine, quinidine, sotalol, dronedarone, indapamide
Full monographs, dosing and an interaction checker in the MediHelp app
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