Drug interactions
Amlodipine-olmesartan + Aspirin / citric acid / sodium bicarbonate
Severity: Moderate
Amlodipine-olmesartan and Aspirin / citric acid / sodium bicarbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product is given at analgesic doses and can blunt olmesartan's blood pressure effect while increasing renal injury risk. The sodium load may also work against blood pressure control.
What this interaction means in plain words
Amlodipine-olmesartan and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, reducing renal perfusion and antagonizing ARB effects; sodium bicarbonate adds sodium load.
What to do
Limit frequent use, monitor blood pressure, creatinine and potassium, and keep patients hydrated. Consider paracetamol as an alternative for occasional pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Aspirin / citric acid / sodium bicarbonate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product is given at analgesic doses and can blunt olmesartan's blood pressure effect while increasing renal injury risk. The sodium load may also work against blood pressure control.
How serious is the interaction between Amlodipine-olmesartan and Aspirin / citric acid / sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit frequent use, monitor blood pressure, creatinine and potassium, and keep patients hydrated. Consider paracetamol as an alternative for occasional pain.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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