Drug interactions
Amlodipine-olmesartan + Aspirin rectal
Severity: Moderate
Amlodipine-olmesartan and Aspirin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and at analgesic doses can reduce olmesartan efficacy and impair renal function. Risk is higher in the elderly or volume-depleted.
What this interaction means in plain words
Amlodipine-olmesartan and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition reduces renal blood flow and opposes the effect of angiotensin receptor blockade.
What to do
Monitor blood pressure, serum creatinine and potassium with regular use, and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Aspirin rectal?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and at analgesic doses can reduce olmesartan efficacy and impair renal function. Risk is higher in the elderly or volume-depleted.
How serious is the interaction between Amlodipine-olmesartan and Aspirin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium with regular use, and maintain hydration.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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