Drug interactions
Amlodipine-olmesartan + Aspirin
Severity: Moderate
Amlodipine-olmesartan and Aspirin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses, aspirin can blunt the effect of olmesartan and worsen renal function, especially in elderly or volume-depleted patients. Low-dose cardioprotective aspirin has much less effect.
What this interaction means in plain words
Amlodipine-olmesartan and Aspirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits vasodilatory renal prostaglandins, reducing renal perfusion and opposing angiotensin receptor blocker effects.
What to do
Monitor blood pressure, creatinine and potassium when higher-dose aspirin is used, and ensure hydration. Low-dose aspirin usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Aspirin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Aspirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses, aspirin can blunt the effect of olmesartan and worsen renal function, especially in elderly or volume-depleted patients. Low-dose cardioprotective aspirin has much less effect.
How serious is the interaction between Amlodipine-olmesartan and Aspirin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium when higher-dose aspirin is used, and ensure hydration. Low-dose aspirin usually needs no change.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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