Drug interactions
Amlodipine-olmesartan + Bendroflumethiazide
Severity: Minor
Amlodipine-olmesartan and Bendroflumethiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an angiotensin receptor blocker with a thiazide diuretic is a common and effective antihypertensive strategy. The two drugs have additive blood pressure lowering, and the thiazide's potassium loss is partly offset by olmesartan. Excess hypotension, volume depletion or electrolyte disturbance can occur, especially at treatment start.
What this interaction means in plain words
Amlodipine-olmesartan and Bendroflumethiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic blood pressure lowering, with opposing effects on potassium: ARB reduces aldosterone-mediated potassium loss while thiazide increases renal potassium excretion.
What to do
Check blood pressure, serum potassium and sodium and renal function after starting or changing doses. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Bendroflumethiazide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Bendroflumethiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining an angiotensin receptor blocker with a thiazide diuretic is a common and effective antihypertensive strategy. The two drugs have additive blood pressure lowering, and the thiazide's potassium loss is partly offset by olmesartan. Excess hypotension, volume depletion or electrolyte disturbance can occur, especially at treatment start.
How serious is the interaction between Amlodipine-olmesartan and Bendroflumethiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure, serum potassium and sodium and renal function after starting or changing doses. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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